Sugar Matters: Improving In Vivo Clearance Rate of Highly Glycosylated Recombinant Plasma Proteins for Therapeutic Use

• Main Authors: Sacha Zeerleder (Author), Ruchira Engel (Author), Tao Zhang (Author), Dorina Roem (Author), Gerard van Mierlo (Author), Ineke Wagenaar-Bos (Author), Sija Marieke van Ham (Author), Manfred Wuhrer (Author), Diana Wouters (Author), Ilse Jongerius (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Correct glycosylation of proteins is essential for production of therapeutic proteins as glycosylation is important for protein solubility, stability, half-life and immunogenicity. The heavily glycosylated plasma protein C1-inhibitor (C1-INH) is used in treatment of hereditary angioedema attacks. In...