A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis

• Main Authors: Zhejie Chen (Author), Wei Hao (Author), Caifang Gao (Author), Yangyang Zhou (Author), Chen Zhang (Author), Jinming Zhang (Author), Ruibing Wang (Author), Yitao Wang (Author), Shengpeng Wang (Author)
• Format: Book
• Published: Elsevier, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With the development of synthesis technology, modified messenger RNA (mRNA) has emerged as a novel category of therapeutic agents for a broad of diseases. However, effective intracellular delivery of mRNA remains challenging, especially for its sensitivity to enzymatic degradation. Here, we propose...