Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Impairs Host Defense in Experimental Melioidosis.

• Main Authors: Tassili A F Weehuizen (Author), Tijmen J Hommes (Author), Jacqueline M Lankelma (Author), Hanna K de Jong (Author), Joris J T H Roelofs (Author), Alex F de Vos (Author), Marco Colonna (Author), Tom van der Poll (Author), W Joost Wiersinga (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triggering receptor expressed on myeloid cells (TREM) -1 and TREM-2 are key regulators of the inflammatory response that are involved in the clearance of invading pathogens. Melioidosis, caused by the "Tier 1" biothreat agent Burkholderia pseudomallei, is a common form of community-acquire...