The gene silencing of IRF5 and BLYSS effectively modulates the outcome of experimental lupus nephritis

• Main Authors: Jordi Guiteras (Author), Élia Ripoll (Author), Núria Bolaños (Author), Laura De Ramon (Author), Pere Fontova (Author), Núria Lloberas (Author), Josep Maria Cruzado (Author), Josep Maria Aràn (Author), Anna Aviñó (Author), Ramon Eritja (Author), Montse Gomà (Author), Rosario Taco (Author), Josep Maria Grinyó (Author), Juan Torras (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Systemic lupus erythematosus is a highly complex and heterogeneous autoimmune disease mostly mediated by B cells. It is characterized by circulating self-reactive antibodies that deposit and form immune complexes in kidney, leading to irreparable tissue damage and resulting in lupus nephritis. In a...