Characterization of T cell responses to co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in healthy adults in Gabon.

• Main Authors: Yoanne D Mouwenda (Author), Madeleine E Betouke Ongwe (Author), Friederike Sonnet (Author), Koen A Stam (Author), Lucja A Labuda (Author), Sophie De Vries (Author), Martin P Grobusch (Author), Frejus J Zinsou (Author), Yabo J Honkpehedji (Author), Jean-Claude Dejon Agobe (Author), David J Diemert (Author), Remko van Leeuwen (Author), Maria E Bottazzi (Author), Peter J Hotez (Author), Peter G Kremsner (Author), Jeffrey M Bethony (Author), Simon P Jochems (Author), Ayola A Adegnika (Author), Marguerite Massinga Loembe (Author), Maria Yazdanbakhsh (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Two hookworm vaccine candidates, Na-GST-1 and Na-APR-1, formulated with Glucopyranosyl Lipid A (GLA-AF) adjuvant, have been shown to be safe, well tolerated, and to induce antibody responses in a Phase 1 clinical trial (Clinicaltrials.gov NCT02126462) conducted in Gabon. Here, we characterized T cel...