Robust COX-2-mediated prostaglandin response may drive arthralgia and bone destruction in patients with chronic inflammation post-chikungunya.

• Main Authors: Yosra Bedoui (Author), Axelle Septembre-Malaterre (Author), Claude Giry (Author), Marie-Christine (Author), Jimmy Selambarom (Author), Pascale Guiraud (Author), Philippe Gasque (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients following infection by chikungunya virus (CHIKV) can suffer for months to years from arthralgia and arthritis. Interestingly, methotrexate (MTX) a major immune-regulatory drug has proved to be of clinical benefit. We have previously shown that CHIKV can persist in the joint of one patient 1...