Iron Complexation to Histone Deacetylase Inhibitors SAHA and LAQ824 in PEGylated Liposomes Can Considerably Improve Pharmacokinetics in Rats

• Main Authors: Yan Wang (Author), Sheng Tu (Author), Dana Steffen (Author), May Xiong (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2015-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

PURPOSE. The formulation of histone deacetylase inhibitors (HDACi) is challenging due to poor water solubility and rapid elimination of drugs in vivo. This study investigated the effects of complexing iron (Fe3+) to the HDACi suberoylanilide hydroxamic acid (SAHA) and LAQ824 (LAQ) prior to their enc...