Iron Complexation to Histone Deacetylase Inhibitors SAHA and LAQ824 in PEGylated Liposomes Can Considerably Improve Pharmacokinetics in Rats

PURPOSE. The formulation of histone deacetylase inhibitors (HDACi) is challenging due to poor water solubility and rapid elimination of drugs in vivo. This study investigated the effects of complexing iron (Fe3+) to the HDACi suberoylanilide hydroxamic acid (SAHA) and LAQ824 (LAQ) prior to their enc...

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Asıl Yazarlar: Yan Wang (Yazar), Sheng Tu (Yazar), Dana Steffen (Yazar), May Xiong (Yazar)
Materyal Türü: Kitap
Baskı/Yayın Bilgisi: Frontiers Media S.A., 2015-01-01T00:00:00Z.
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Yer Numarası: A1234.567
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