Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice

• Główni autorzy: Vicki Xie (Autor), Daochen Tong (Autor), Craig T. Wallington-Beddoe (Autor), Ken F. Bradstock (Autor), Linda J. Bendall (Autor)
• Format: Książka
• Wydane: BMC, 2018-02-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract Background Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the development of acute lymphoblastic leukemia (ALL). Methods In this and o...