Using quantitative systems pharmacology modeling to optimize combination therapy of anti-PD-L1 checkpoint inhibitor and T cell engager

• मुख्य लेखकों: Samira Anbari (लेखक), Hanwen Wang (लेखक), Yu Zhang (लेखक), Jun Wang (लेखक), Minu Pilvankar (लेखक), Masoud Nickaeen (लेखक), Steven Hansel (लेखक), Aleksander S. Popel (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Although immune checkpoint blockade therapies have shown evidence of clinical effectiveness in many types of cancer, the outcome of clinical trials shows that very few patients with colorectal cancer benefit from treatments with checkpoint inhibitors. Bispecific T cell engagers (TCEs) are gaining po...