Using quantitative systems pharmacology modeling to optimize combination therapy of anti-PD-L1 checkpoint inhibitor and T cell engager

• Main Authors: Samira Anbari (Author), Hanwen Wang (Author), Yu Zhang (Author), Jun Wang (Author), Minu Pilvankar (Author), Masoud Nickaeen (Author), Steven Hansel (Author), Aleksander S. Popel (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although immune checkpoint blockade therapies have shown evidence of clinical effectiveness in many types of cancer, the outcome of clinical trials shows that very few patients with colorectal cancer benefit from treatments with checkpoint inhibitors. Bispecific T cell engagers (TCEs) are gaining po...