Supercoiled DNA percentage: A key in-process control of linear DNA template for mRNA drug substance manufacturing
The development of messenger RNA (mRNA) vaccines and therapeutics necessitates the production of high-quality in vitro-transcribed mRNA drug substance with specific critical quality attributes (CQAs), which are closely tied to the uniformity of linear DNA template. The supercoiled plasmid DNA is the...
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Elsevier,
2024-06-01T00:00:00Z.
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