Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response

• Main Authors: Jennifer M. Rojas (Author), Miles E. Matsen (Author), Thomas O. Mundinger (Author), Gregory J. Morton (Author), Darko Stefanovski (Author), Richard N. Bergman (Author), Karl J. Kaiyala (Author), Gerald J. Taborsky Jr (Author), Michael W. Schwartz (Author)
• Format: Book
• Published: Elsevier, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Central administration of ligands for fibroblast growth factor receptors (FGFRs) such as fibroblast growth factor-19 (FGF19) and FGF21 exert glucose-lowering effects in rodent models of obesity and type 2 diabetes (T2D). Conversely, intracerebroventricular (icv) administration of the non-...