Discovery of genistein derivatives as potential SARS-CoV-2 main protease inhibitors by virtual screening, molecular dynamics simulations and ADMET analysis

• Main Authors: Jiawei Liu (Author), Ling Zhang (Author), Jian Gao (Author), Baochen Zhang (Author), Xiaoli Liu (Author), Ninghui Yang (Author), Xiaotong Liu (Author), Xifu Liu (Author), Yu Cheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Due to the constant mutation of virus and the lack of specific therapeutic drugs, the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) still poses a huge threat to the health of people, especially those with underlyin...