Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

• Main Authors: Nhu Truong (Author), Andrea L. Cottingham (Author), Shruti Dharmaraj (Author), Jacob R. Shaw (Author), Jackline Joy Martin Lasola (Author), Christopher C. Goodis (Author), Steven Fletcher (Author), Ryan M. Pearson (Author)
• Format: Book
• Published: Wiley, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA‐OH...