Population Pharmacokinetics of Palbociclib and Its Correlation with Clinical Efficacy and Safety in Patients with Advanced Breast Cancer

• Main Authors: Perrine Courlet (Author), Evelina Cardoso (Author), Carole Bandiera (Author), Athina Stravodimou (Author), Jean-Philippe Zurcher (Author), Haithem Chtioui (Author), Isabella Locatelli (Author), Laurent Arthur Decosterd (Author), Léa Darnaud (Author), Benoit Blanchet (Author), Jérôme Alexandre (Author), Anna Dorothea Wagner (Author), Khalil Zaman (Author), Marie Paule Schneider (Author), Monia Guidi (Author), Chantal Csajka (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neutropenia is the most frequent dose-limiting toxicity reported in patients with metastatic breast cancer receiving palbociclib. The objective of this study was to investigate the pharmacokinetic-pharmacodynamic (PK/PD) relationships for toxicity (i.e., absolute neutrophil count, ANC) and efficacy...