In Vivo TLR9 Inhibition Attenuates CpG-Induced Myocardial Dysfunction

• Main Authors: O. Boehm (Author), P. Markowski (Author), M. van der Giet (Author), V. Gielen (Author), A. Kokalova (Author), C. Brill (Author), A. Hoeft (Author), G. Baumgarten (Author), R. Meyer (Author), P. Knuefermann (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The involvement of toll-like receptor 9 (TLR9), a receptor for bacterial DNA, in septic cardiac depression has not been clarified in vivo. Thus, the aim of the study was to test possible TLR9 inhibitors (H154-thioate, IRS954-thioate, and chloroquine) for their ability to protect the cardiovascular s...