Pharmacological Significance of the Blocking Action of the Intravenous General Anesthetic Propofol on the Slow Component of Cardiac Delayed Rectifier K+ Current

• Main Authors: Noboru Hatakeyama (Author), Fumika Sakuraya (Author), Naoyuki Matsuda (Author), Junko Kimura (Author), Hiroyuki Kinoshita (Author), Osamu Kemmotsu (Author), Mitsuaki Yamazaki (Author), Yuichi Hattori (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Propofol is a widely used intravenous general anesthetic. The negative inotropic effect of propofol has been best explained by inhibition of the L-type Ca2+ current (ICa). Using guinea-pig cardiac preparations, however, we found that the propofol concentration producing a 50% decrease in...