M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

• Main Authors: Ha Eun Shin (Author), Jun-Hyeok Han (Author), Seungyong Shin (Author), Ga-Hyun Bae (Author), Boram Son (Author), Tae-Hyung Kim (Author), Hee Ho Park (Author), Chun Gwon Park (Author), Wooram Park (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene therapy. Lipid nanoparticles (LNPs), considered a prospective vehicle for nucleic acid delivery, have demonstrated efficacy in human use during the COVID-19 pandemic. This study introduces...