Stability Study, Quantification Method and Pharmacokinetics Investigation of a Coumarin-Monoterpene Conjugate Possessing Antiviral Properties against Respiratory Syncytial Virus

• Main Authors: Arina G. Nemolochnova (Author), Artem D. Rogachev (Author), Olga P. Salnikova (Author), Tatyana M. Khomenko (Author), Konstantin P. Volcho (Author), Olga I. Yarovaya (Author), Alina V. Fatianova (Author), Andrey G. Pokrovsky (Author), Nariman F. Salakhutdinov (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The stability of a new coumarin derivative, agent K-142, bearing α-pinene residue and possessing antiviral activity against respiratory syncytial virus (RSV) was studied in whole mice blood in vitro, and a method for its quantification in this matrix was developed and validated. The sample preparati...