A DNA/RNA heteroduplex oligonucleotide coupling asparagine depletion restricts FGFR2 fusion-driven intrahepatic cholangiocarcinoma

• मुख्य लेखकों: Zhenzhen Chu (लेखक), Baohuan Zhang (लेखक), Xuxuan Zhou (लेखक), Hui Yuan (लेखक), Chongqing Gao (लेखक), Lihao Liu (लेखक), Yang Xiao (लेखक), Jichun Zhang (लेखक), Jian Hong (लेखक), Junjie Liang (लेखक), Dong Chen (लेखक), Nan Yao (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Pemigatinib, a pan-FGFR inhibitor, is approved to treat intrahepatic cholangiocarcinoma (ICC) harboring FGFR2 fusion mutations. Improving its targeting of FGFR2 fusions remains an unmet clinical need due to its pan selectivity and resistance. Here, we report a cholesterol-conjugated DNA/RNA heterodu...