Dencichine prevents ovariectomy-induced bone loss and inhibits osteoclastogenesis by inhibiting RANKL-associated NF-κB and MAPK signaling pathways

• Main Authors: Dingwei Cang (Author), Guoyou Zou (Author), Chi Yang (Author), Xiaofei Shen (Author), Feng Li (Author), Ya Wu (Author), Biao Ji (Author)
• Format: Book
• Published: Elsevier, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: To investigate the effect of dencichine on osteoclastogenesis in vivo and in vitro. Methods: RANKL-induced osteoclastogenesis were treated with different concentrations of dencichine. Pit forming assays were applied to evaluate the degree of bone resorption. Osteoclastogenic markers were detec...