A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers

• Main Authors: Pascual Torres (Author), Carlos Anerillas (Author), Omar Ramírez-Núñez (Author), Anna Fernàndez (Author), Mario Encinas (Author), Mònica Povedano (Author), Pol Andrés-Benito (Author), Isidre Ferrer (Author), Victòria Ayala (Author), Reinald Pamplona (Author), Manuel Portero-Otín (Author)
• Format: Book
• Published: The Company of Biologists, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To evaluate senescence mechanisms, including senescence-associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase (SA-β-gal) in nervous tissue. As SASP markers, we measured the mRNA level...