Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities

The hERG (human ether-a-go-go-related gene) encoded potassium ion (K+) channel plays a major role in cardiac repolarization. Drug-induced blockade of hERG has been a major cause of potentially lethal ventricular tachycardia termed Torsades de Pointes (TdPs). Therefore, we presented a pharmacoinforma...

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Bibliographic Details
Main Authors: Saba Munawar (Author), Monique J. Windley (Author), Edwin G. Tse (Author), Matthew H. Todd (Author), Adam P. Hill (Author), Jamie I. Vandenberg (Author), Ishrat Jabeen (Author)
Format: Book
Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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