2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function

2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function

Abstract Background High mobility group box 1 protein (HMGB1) is an alarmin following its release by immune cells upon cellular activation or stress. High levels of extracellular HMGB1 play a critical role in impairing the clearance of invading pulmonary pathogens and dying neutrophils in the injure...

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Main Authors: Mao Wang (Author), Alex G. Gauthier (Author), Thomas P. Kennedy (Author), Haichao Wang (Author), Uday Kiran Velagapudi (Author), Tanaji T. Talele (Author), Mosi Lin (Author), Jiaqi Wu (Author), LeeAnne Daley (Author), Xiaojing Yang (Author), Vivek Patel (Author), Sung Soo Mun (Author), Charles R. Ashby (Author), Lin L. Mantell (Author)
Format: Book
Published: BMC, 2021-07-01T00:00:00Z.
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3rd Floor Main Library

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