Therapeutic targeting of PARP with immunotherapy in acute myeloid leukemia

Targeting the poly (ADP-ribose) polymerase (PARP) protein has shown therapeutic efficacy in cancers with homologous recombination (HR) deficiency due to BRCA mutations. Only small fraction of acute myeloid leukemia (AML) cells carry BRCA mutations, hence the antitumor efficacy of PARP inhibitors (PA...

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Bibliographic Details
Main Authors: Xing Bian (Author), Wenli Liu (Author), Kaijin Yang (Author), Chuanbo Sun (Author)
Format: Book
Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
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3rd Floor Main Library

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