Therapeutic targeting of PARP with immunotherapy in acute myeloid leukemia
Targeting the poly (ADP-ribose) polymerase (PARP) protein has shown therapeutic efficacy in cancers with homologous recombination (HR) deficiency due to BRCA mutations. Only small fraction of acute myeloid leukemia (AML) cells carry BRCA mutations, hence the antitumor efficacy of PARP inhibitors (PA...
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Frontiers Media S.A.,
2024-08-01T00:00:00Z.
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