Human DNA Telomeres in Presence of Oxidative Lesions: The Crucial Role of Electrostatic Interactions on the Stability of Guanine Quadruplexes

• मुख्य लेखकों: Cecilia Hognon (लेखक), Adrien Gebus (लेखक), Giampaolo Barone (लेखक), Antonio Monari (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2019-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

By using all atom molecular dynamics simulations, we studied the behavior of human DNA telomere sequences in guanine quadruplex (G4) conformation and in the presence of oxidative lesions, namely abasic sites. In particular, we evidenced that while removing one guanine base induces a significant alte...