Human DNA Telomeres in Presence of Oxidative Lesions: The Crucial Role of Electrostatic Interactions on the Stability of Guanine Quadruplexes

• Asıl Yazarlar: Cecilia Hognon (Yazar), Adrien Gebus (Yazar), Giampaolo Barone (Yazar), Antonio Monari (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2019-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

By using all atom molecular dynamics simulations, we studied the behavior of human DNA telomere sequences in guanine quadruplex (G4) conformation and in the presence of oxidative lesions, namely abasic sites. In particular, we evidenced that while removing one guanine base induces a significant alte...