CYP2B6 Genotype‐Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers

• Main Authors: Ingrid F. Metzger (Author), Nimita Dave (Author), Yvonne Kreutz (Author), Jessica B.L. Lu (Author), Raymond E. Galinsky (Author), Zeruesenay Desta (Author)
• Format: Book
• Published: Wiley, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effect of efavirenz on the activities of cytochrome P450 (CYP)1A2, CYP2A6, xanthine oxidase (XO), and N‐acetyltransferase 2 (NAT2), using caffeine as a probe. A single 150 mg oral dose of caffeine was administered to healthy volunteers (n = 58) on two separate occasions; with a s...