In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease

• Main Authors: Martine Aubert (Author), Nicole M Boyle (Author), Daniel Stone (Author), Laurence Stensland (Author), Meei-Li Huang (Author), Amalia S Magaret (Author), Roman Galetto (Author), David J Rawlings (Author), Andrew M Scharenberg (Author), Keith R Jerome (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Following acute infection, herpes simplex virus (HSV) establishes latency in sensory neurons, from which it can reactivate and cause recurrent disease. Available antiviral therapies do not affect latent viral genomes; therefore, they do not prevent reactivation following therapy cessation. One possi...