Design and Synthesis of a Novel 4-aryl-N-(2-alkoxythieno [2,3-<i>b</i>]pyrazine-3-yl)-4-arylpiperazine-1-carboxamide DGG200064 Showed Therapeutic Effect on Colon Cancer through G2/M Arrest

• Main Authors: Eun-Sil Lee (Author), Nayeon Kim (Author), Joon Hee Kang (Author), Aizhan Abdildinova (Author), Seon-Hyeong Lee (Author), Myung Hwi Lee (Author), Nam Sook Kang (Author), Tae-Sung Koo (Author), Soo-Youl Kim (Author), Young-Dae Gong (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer cells are characterized by an abnormal cell cycle. Therefore, the cell cycle has been a potential target for cancer therapeutic agents. We developed a new lead compound, <b>DGG200064</b> (<b>7c</b>) with a 2-alkoxythieno [2,3-<i>b</i>]pyrazine-3-yl)-4-arylp...