A CRM1 Inhibitor Alleviates Cardiac Hypertrophy and Increases the Nuclear Distribution of NT-PGC-1α in NRVMs

• Main Authors: Zuheng Liu (Author), Haiping Tian (Author), Jinghai Hua (Author), Wanqiang Cai (Author), Yujia Bai (Author), Qiong Zhan (Author), Wenyan Lai (Author), Qingchun Zeng (Author), Hao Ren (Author), Dingli Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chromosomal maintenance 1 (CRM1) inhibitors display antihypertrophic effects and control protein trafficking between the nucleus and the cytoplasm. PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1alpha) is a type of transcriptional coactivator that predominantly resides in the...