TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton

• Main Authors: Mona Elsafadi (Author), Muthurangan Manikandan (Author), Sami Almalki (Author), Mohammad Mobarak (Author), Muhammad Atteya (Author), Zafar Iqbal (Author), Jamil Amjad Hashmi (Author), Sameerah Shaheen (Author), Nehad Alajez (Author), Musaad Alfayez (Author), Moustapha Kassem (Author), Raed Abu Dawud (Author), Amer Mahmood (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TGFβ is a potent regulator of several biological functions in many cell types, but its role in the differentiation of human bone marrow-derived skeletal stem cells (hMSCs) is currently poorly understood. In the present study, we demonstrate that a single dose of TGFβ1 prior to induction of osteogeni...