Nafamostat Mesilate Induces Production of Interleukin-12 and -18 in Human Peripheral Blood Mononuclear Cells

• Main Authors: Goutarou Katsuno (Author), Hideo K. Takahashi (Author), Hiromi Iwagaki (Author), Kenji Mizuno (Author), Shuji Mori (Author), Tadashi Yoshino (Author), Masahiro Nishibori (Author), Noriaki Tanaka (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7....