The Epoxy Group of Pramanicin Is Required for the Optimal Endothelium-Dependent Relaxation of Rat Aorta

• Main Authors: Chiu-Yin Kwan (Author), Wen-Bo Zhang (Author), Joanna Miller (Author), Paul H.M. Harrison (Author), Salina Kassan (Author), David Liscombe (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The vascular effects of a newly discovered anti-fungal agent, pramanicin (PMC), and its two analogues, PMC-A, in which the epoxy group is replaced by a - HC = CH - bond, and PMC-B, on which the diene is converted to the saturated (CH2)4-derivative, respectively, were investigated in rat aorta. All t...