Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

• Main Authors: Guang Yang (Author), Haiyan Chen (Author), Qun Chen (Author), Jiayi Qiu (Author), Mulan Qahar (Author), Zhimeng Fan (Author), Weiwei Chu (Author), Edward E. Tredget (Author), Yaojiong Wu (Author)
• Format: Book
• Published: BMC, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The hair follicles (HFs) are barely regenerated after loss in injuries in mammals as well as in human beings. Recent studies have shown that the regenerative ability of HFs is age-related; however, the relationship between this phenomenon and the stem cell niche remains unclear....