Shugan Decoction Alleviates Colonic Dysmotility in Female SERT-Knockout Rats by Decreasing M3 Receptor Expression

• Main Authors: Yinshu Wang (Author), Ying Dong (Author), Enkang Wang (Author), Yangyang Meng (Author), Zijuan Bi (Author), Shuai Sun (Author), Chaochao Zhang (Author), Haiting Fan (Author), Jianye Yuan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundIrritable bowel syndrome (IBS) is a functional gut disease characterized by visceral hypersensitivity and gut motor dysfunction. Serotonin (5-hydroxytryptamine, 5-HT) is an important enteric neurotransmitter. High levels of 5-HT aggravate IBS symptoms. The serotonin reuptake transporter (S...