Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair

• Κύριοι συγγραφείς: Kankan Wang (Συγγραφέας), Xiaochun Tang (Συγγραφέας), Yan Liu (Συγγραφέας), Zicong Xie (Συγγραφέας), Xiaodong Zou (Συγγραφέας), Mengjing Li (Συγγραφέας), Hongming Yuan (Συγγραφέας), Hongsheng Ouyang (Συγγραφέας), Huping Jiao (Συγγραφέας), Daxin Pang (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2016-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Precise genome editing in livestock is of great value for the fundamental investigation of disease modeling. However, genetically modified pigs carrying subtle point mutations were still seldom reported despite the rapid development of programmable endonucleases. Here, we attempt to investigate sing...