Combination of thermal ablation by focused ultrasound, pFAR4-IL-12 transfection and lipidic adjuvant provide a distal immune response

• Main Authors: Hai Doan Do (Author), Corinne Marie (Author), Stéphanie Bessoles (Author), Hélène Dhotel (Author), Johanne Seguin (Author), Benoit Larrat (Author), Bich-Thuy Doan (Author), Daniel Scherman (Author), Virginie Escriou (Author), Salima Hacein- (Author), Nathalie Mignet (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Gene-based immunotherapy against cancer is limited by low gene transfer efficiency. In the literature, interleukin-12 (IL-12) encoding plasmid associated with sonoporation has been shown to enhance antitumoral activity. Moreover, non-viral carriers and high-frequency ultrasound have both been s...