Combating Acute Myeloid Leukemia via Sphingosine Kinase 1 Inhibitor-Nanomedicine Combination Therapy with Cytarabine or Venetoclax

• Main Authors: Thao M. Nguyen (Author), Paul Joyce (Author), David M. Ross (Author), Kristen Bremmell (Author), Manasi Jambhrunkar (Author), Sook S. Wong (Author), Clive A. Prestidge (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2024-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

MP-A08 is a novel sphingosine kinase 1 (SPHK1) inhibitor with activity against acute myeloid leukemia (AML). A rationally designed liposome-based encapsulation and delivery system has been shown to overcome the physicochemical challenges of MP-A08 and enable its effective delivery for improved effic...