QT PRODACT: In Vivo QT Assay With a Conscious Monkey for Assessment of the Potential for Drug-Induced QT Interval Prolongation

• Main Authors: Kentaro Ando (Author), Toshiyasu Hombo (Author), Akihiro Kanno (Author), Hironobu Ikeda (Author), Masakazu Imaizumi (Author), Noritsugu Shimizu (Author), Kengo Sakamoto (Author), Shin-ichi Kitani (Author), Yoshinori Yamamoto (Author), Shingo Hizume (Author), Keiko Nakai (Author), Tetsuya Kitayama (Author), Keiji Yamamoto (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In safety pharmacology studies, the effects on the QT interval of electrocardiograms are routinely assessed using a telemetry system in cynomolgus monkeys. However, there is a lack of integrated databases concerning in vivo QT assays in conscious monkeys. As part of QT Interval Prolongation: Project...