Au-24 as a potential thioredoxin reductase inhibitor in hepatocellular carcinoma cells

• Auteurs principaux: Gaopan Dong (Auteur), Xiaohan Ye (Auteur), Shumei Wang (Auteur), Wenhua Li (Auteur), Rong Cai (Auteur), Lupei Du (Auteur), Xiaodong Shi (Auteur), Minyong Li (Auteur)
• Format: Livre
• Publié: Elsevier, 2022-03-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

A novel TrxR inhibitor Au-24 and its inhibitory ability to hepatocellular carcinoma in vitro and in vivo is reported herein. Au-24 can suppress HepG2 cells from proliferating by lowering mitochondrial membrane potential (MMP) and increasing reactive oxygen species (ROS) levels, resulting in oxidativ...