Au-24 as a potential thioredoxin reductase inhibitor in hepatocellular carcinoma cells

• Main Authors: Gaopan Dong (Author), Xiaohan Ye (Author), Shumei Wang (Author), Wenhua Li (Author), Rong Cai (Author), Lupei Du (Author), Xiaodong Shi (Author), Minyong Li (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel TrxR inhibitor Au-24 and its inhibitory ability to hepatocellular carcinoma in vitro and in vivo is reported herein. Au-24 can suppress HepG2 cells from proliferating by lowering mitochondrial membrane potential (MMP) and increasing reactive oxygen species (ROS) levels, resulting in oxidativ...