Dose Finding and Food Effect Studies of a Novel Abiraterone Acetate Formulation for Oral Suspension in Comparison to a Reference Formulation in Healthy Male Subjects

• Main Authors: Tamás Jordán (Author), Orsolya Basa-Dénes (Author), Réka Angi (Author), János Orosz (Author), Zsolt Ötvös (Author), Andrea Ujhelyi (Author), Genovéva Filipcsei (Author), László Molnár (Author), Tamás Solymosi (Author), Hristos Glavinas (Author), Dominic Capone (Author), Nicola Whitfield (Author), John McDermott (Author), Litza McKenzie (Author), Lauren Shurety (Author), Elizabeth Manning Duus (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2021-12-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Currently approved formulations of the androgen synthesis inhibitor abiraterone acetate (AA) consist of multiple tablets administered daily in a fasted state. Removing the food effect and switching to a suspension formulation is expected to improve the pharmacokinetic profile and facilitate drug adm...