Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance

• Main Authors: Mingzhu He (Author), Marco E. Bianchi (Author), Tom R. Coleman (Author), Kevin J. Tracey (Author), Yousef Al-Abed (Author)
• Format: Book
• Published: BMC, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background High Mobility Group Box 1 (HMGB1) was first identified as a nonhistone chromatin-binding protein that functions as a pro-inflammatory cytokine and a Damage-Associated Molecular Pattern molecule when released from necrotic cells or activated leukocytes. HMGB1 consists of two struc...