Histidine residues at the copper-binding site in human tyrosinase are essential for its catalytic activities

• Main Authors: Hyangsoon Noh (Author), Sung Jun Lee (Author), Hyun-Joo Jo (Author), Hye Won Choi (Author), Sungguan Hong (Author), Kwang-Hoon Kong (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tyrosinase is a copper-binding enzyme involved in melanin biosynthesis. However, the detailed structure of human tyrosinase has not yet been solved, along with the identification of the key sites responsible for its catalytic activity. We used site-directed mutagenesis to identify the residues criti...