Tuning Scorpion Toxin Selectivity: Switching From KV1.1 to KV1.3

• Main Authors: Andrei M. Gigolaev (Author), Alexey I. Kuzmenkov (Author), Steve Peigneur (Author), Valentin M. Tabakmakher (Author), Ernesto L. Pinheiro-Junior (Author), Anton O. Chugunov (Author), Roman G. Efremov (Author), Jan Tytgat (Author), Alexander A. Vassilevski (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Voltage-gated potassium channels (KVs) perform vital physiological functions and are targets in different disorders ranging from ataxia and arrhythmia to autoimmune diseases. An important issue is the search for and production of selective ligands of these channels. Peptide toxins found in scorpion...