Design, synthesis, and biological evaluation of multiple targeting antimalarials

• Principais autores: Yiqing Yang (Autor), Tongke Tang (Autor), Xiaolu Li (Autor), Thomas Michel (Autor), Liqin Ling (Autor), Zhenghui Huang (Autor), Maruthi Mulaka (Autor), Yue Wu (Autor), Hongying Gao (Autor), Liguo Wang (Autor), Jing Zhou (Autor), Brigitte Meunier (Autor), Hangjun Ke (Autor), Lubin Jiang (Autor), Yu Rao (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2021-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Malaria still threatens global health seriously today. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug resistance. Here, we performed a structure-bas...