The Triterpenoid CDDO-Methyl Ester Redirects Macrophage Polarization and Reduces Lung Tumor Burden in a Nrf2-Dependent Manner

• Główni autorzy: Jessica A. Moerland (Autor), Ana S. Leal (Autor), Beth Lockwood (Autor), Elena Y. Demireva (Autor), Huirong Xie (Autor), Teresa Krieger-Burke (Autor), Karen T. Liby (Autor)
• Format: Książka
• Wydane: MDPI AG, 2023-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The NRF2/KEAP1 pathway protects healthy cells from malignant transformation and maintains cellular homeostasis. Up to 30% of human lung tumors gain constitutive NRF2 activity which contributes to cancer cell survival and chemoresistance, but the effects of NRF2 activation in immune cells within the...