Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate

Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate

Introduction: High dose methotrexate (HD-Mtx) is highly effective and significantly improves overall acute lymphoblastic leukemia (ALL) patients survival. The pharmacodynamics of Mtx depends on the polymorphism of genes encoding proteins engaged in the folate metabolism pathway. The aim of the curre...

Full description

Saved in:
Bibliographic Details
Main Authors: Magdalena Cwiklinska (Author), Malgorzata Czogala (Author), Kinga Kwiecinska (Author), Anna Madetko-Talowska (Author), Malgorzata Szafarz (Author), Katarzyna Pawinska (Author), Aleksandra Wieczorek (Author), Tomasz Klekawka (Author), Magdalena Rej (Author), Konrad Stepien (Author), Przemyslaw Halubiec (Author), Agnieszka Lazarczyk (Author), Karol Miklusiak (Author), Miroslaw Bik-Multanowski (Author), Walentyna Balwierz (Author), Szymon Skoczen (Author)
Format: Book
Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
Subjects:
article
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

Connect to this object online.

3rd Floor Main Library

Holdings details from 3rd Floor Main Library
Call Number: A1234.567
Copy 1 Available

Similar Items