Arctiin-encapsulated DSPE-PEG bubble-like nanoparticles inhibit alveolar epithelial type 2 cell senescence to alleviate pulmonary fibrosis via the p38/p53/p21 pathway

• Main Authors: Dian Xiong (Author), Fei Gao (Author), Jingbo Shao (Author), Yueyun Pan (Author), Song Wang (Author), Dong Wei (Author), Shugao Ye (Author), Yuan Chen (Author), Rui Chen (Author), Bingqing Yue (Author), Juan Li (Author), Jingyu Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Idiopathic pulmonary fibrosis is a severe and deadly form of diffuse parenchymal lung disease and treatment options are few. Alveolar epithelial type 2 (AEC2) cell senescence is implicated in the pathogenies of IPF. A major bioactive compound from the traditional Chinese medicine Fructus...