Release of High-Mobility Group Box-1 after a Raynaud's Attack Leads to Fibroblast Activation and Interferon-γ Induced Protein-10 Production: Role in Systemic Sclerosis Pathogenesis

• Váldodahkkit: Yehya Al-Adwi (Dahkki), Isabella M. Atzeni (Dahkki), Berber Doornbos-van der Meer (Dahkki), Amaal Eman Abdulle (Dahkki), Anniek M. van Roon (Dahkki), Alja Stel (Dahkki), Harry van Goor (Dahkki), Andries J. Smit (Dahkki), Johanna Westra (Dahkki), Douwe J. Mulder (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2023-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Raynaud's Phenomenon (RP) leading to repetitive ischemia and reperfusion (IR) stress, is the first recognizable sign of systemic sclerosis (SSc) leading to increased oxidative stress. High-mobility group box-1 (HMGB1) is a nuclear factor released by apoptotic and necrotic cells after oxidative...