Safety and Tolerability of KIO-101 Eye Drops in Healthy Volunteers and Patients with Ocular Surface Disease-A Phase I Study

• Main Authors: Doreen Schmidl (Author), Nikolaus Hommer (Author), Martin Kallab (Author), Andreas Schlatter (Author), Clemens Nadvornik (Author), Franz Obermayr (Author), Stefan Sperl (Author), Eric J. Daniels (Author), Gerhard Garhöfer (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2024-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Purpose: Inhibitors of dihydroorotate dehydrogenase (DHODH) have been found to be potent anti-inflammatory agents. Recently, a topical formulation (KIO-101 eye drops) of a DHODH inhibitor has been developed. The aim of the present study was to evaluate the safety and tolerability of KIO-101 eye drop...