Model-Informed Precision Dosing during Infliximab Induction Therapy Reduces Variability in Exposure and Endoscopic Improvement between Patients with Ulcerative Colitis

Model-Informed Precision Dosing during Infliximab Induction Therapy Reduces Variability in Exposure and Endoscopic Improvement between Patients with Ulcerative Colitis

Model-informed precision dosing (MIPD) may be a solution to therapeutic failure of infliximab for patients with ulcerative colitis (UC), as underexposure could be avoided, and the probability of endoscopic improvement (pEI; Mayo endoscopic subscore ≤ 1) could be optimized. To investigate in silico w...

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Main Authors: Ruben Faelens (Author), Zhigang Wang (Author), Thomas Bouillon (Author), Paul Declerck (Author), Marc Ferrante (Author), Séverine Vermeire (Author), Erwin Dreesen (Author)
Format: Book
Published: MDPI AG, 2021-10-01T00:00:00Z.
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