Model-Informed Precision Dosing during Infliximab Induction Therapy Reduces Variability in Exposure and Endoscopic Improvement between Patients with Ulcerative Colitis

• Autori principali: Ruben Faelens (Autore), Zhigang Wang (Autore), Thomas Bouillon (Autore), Paul Declerck (Autore), Marc Ferrante (Autore), Séverine Vermeire (Autore), Erwin Dreesen (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-10-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Model-informed precision dosing (MIPD) may be a solution to therapeutic failure of infliximab for patients with ulcerative colitis (UC), as underexposure could be avoided, and the probability of endoscopic improvement (pEI; Mayo endoscopic subscore ≤ 1) could be optimized. To investigate in silico w...